It was shown that their
Wednesday, December 3rd, 2008Adipose tissue expresses tumornecrosis factor alpha TNF,which could also be involved in IR. Otherwise IGF1 acts asa mitogenic factor and can stimulate cell proliferationand then insulin secretion 29. It was shown that their overproductionis linked to the pathogenesis of this syndrome.
Otherwise IGF1 acts asa mitogenic factor and can stimulate cell proliferationand then insulin secretion 29. This showed that the changes in glucose metabolismobserved in obese dogs suffering from nutritional obesityare reversible, and the treatment of obesity could allow return ofthese variables to normal levels, as previously demonstratedin humans 9. Obesity and overweight are very common in dogs of all Westerncountries 1, increasing the risk of several different diseasessuch as cancers 2,3, osteoarticular disorders, or diabetes4. Because of its structural homology withinsulin, IGF1 can link to insulin receptors and then lead toa decrease in insulin clearance 28.
Because it occurred rapidlyin response to restriction of energy intake we can hypothesizethat the return of TNF and IGF1 plasma concentration are associated withinsulin resistance, in obese dogs, and this could explain, atleast in part, the outbreak of this syndrome 15. Indeed, TNFis known to impair insulin receptor signaling 23. Some studies of obesity in dogs also showed that insulinresistance IR4 is prominent feature 5,6 that could resultfrom changes in the somatotropic axis activity.
Otherwise IGF1 acts asa mitogenic factor and can stimulate cell proliferationand then insulin secretion 29. Hotamisligilet al. Adipose tissue expresses tumornecrosis factor alpha TNF,which could also be involved in IR. It was shown that impairmentin both TNF and IGF1 plasma concentration are associated withinsulin resistance, in obese dogs, and this could explain, atleast in part, the outbreak of this syndrome 15. Because of its structural homology withinsulin, IGF1 can link to insulin receptors and then lead toa decrease in insulin clearance 28. Several studies 24,25 reported an increasein plasma TNF level in obese insulinresistant rodents andhumans 9.
Hotamisligilet al. Receptors thatbind insulin and insulinlike growth factor IGF1 show immunological,structural 7, and functional analogies 8, which could explainthat IGF1 has an insulinlike activity, and participates inIR. It was shown that plasma IGF1 concentrationwas increased in insulinresistant patients 27.
Manystudies in the literature showed that elevated IGF1 concentrationshave an impact on insulin secretion, which could, over time,lead to IR 22,26. Adipose tissue expresses tumornecrosis factor alpha TNF,which could also be involved in IR. Obesity and overweight are very common in dogs of all Westerncountries 1, increasing the risk of several different diseasessuch as cancers 2,3, osteoarticular disorders, or diabetes4. Several studies 24,25 reported an increasein plasma TNF level in obese insulinresistant rodents andhumans 9. It was shown that their overproductionis linked to the pathogenesis of this syndrome 15.