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aurantium alone, because an eightfold higher dose of synephrine Advantra had no effect on blood pressure, but be attributable to caffeine and other stimulants in the multicomponent formulation.. Single doses of These supplements have some of the health risks associated with ephedra, but studies in humans are lacking. Our aim was to characterize the pharmacokinetics and cardiovascular effects of RESULTS Compared with placebo, Xenadrine EFX but not Advantra increased systolic and diastolic blood pressure with peak changes from baseline at hours compared with placebo 16. 7 beats per minute with Advantra 0. 031.
aurantium Advantra containing mg synephrine, and placebo were administered with oneweek washout. RESULTS Compared with placebo, Xenadrine EFX but not Advantra increased systolic and diastolic blood pressure with peak changes from baseline at hours compared with placebo 16. 7 beats per minute with Advantra 0. 031. SUBJECTS AND METHODS Ten healthy adult nonsmokers participated in randomized, doubleblind, placebocontrolled, threearm crossover study. Our aim was to characterize the pharmacokinetics and cardiovascular effects of aurantium alone, because an eightfold higher dose of synephrine Advantra had no effect on blood pressure, but be attributable to caffeine and other stimulants in the multicomponent formulation..
CONCLUSION Ephedrafree weight loss dietary supplements containing bitter orange Citrus aurantium, botanical source of the adrenergic amines synephrine and octopamine, have quickly emerged on consumer markets to replace banned ephedra products. These effects are not likely caused by aurantium dietary supplements. These supplements have some of the health risks associated with ephedra, but studies in humans are lacking. RESULTS Compared with placebo, Xenadrine EFX but not Advantra increased systolic and diastolic blood pressure with peak changes from baseline at hours of mm Hg diastolic 0. 002. aurantium Advantra containing mg synephrine, and placebo were administered with oneweek washout.